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Adenosine 5鈥?triphosphate, periodate oxidized sodium salt has been used:. as an antagonist of the purinergic receptor, P2 x 7 to inhibit P2 x 7 pathway. as a nonspecific agonist to assess the activity of P2x7-R by the mobilization of Ca2+. to evaluate the physiological significance of elevated intracellular ATP levels. increased P2rx7 expression for osteoclastogenesis in Flcn-deficient cells
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