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2,5-Dimethyl-celecoxib has been used. To block the synthesis of prostaglandin E2 and to study effect of transforming growth factor-2 signaling towards cyclooxygenase-2 expression.. In an in vitro study to analyze its pro-oxidative capacities in metastatic melanoma/ breast cancer cells.. To study its interaction between silymarin on chemically induced osteoarthritis in rats.
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