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FK866 hydrochloride hydrate has been used:. to investigate its effects on intra-axonal NAD+ levels. to induce NAD+ depletion. to reduce the level of tumor necrosis factor-伪 (TNF-伪), nicotinamide phosphoribosyltransferase (NAMPT) and interleukin-6 (IL-6) in the ischemic brain tissue