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IWP-2 has been used to treat the cell lines L-Wnt-3a and L-Wnt-5a, to demonstrate the inhibitory effect of IWP-2. It has also been used as a Wnt signaling inhibitor to treat WT and Gja1Jrt/+ stromal cells to confirm that, theWnt/尾-catenin signaling pathway pathway was not involved in the increased marker expression by Gja1Jrt/+ osteoblasts.
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