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STF-083010 has been used:. in a study to investigate the potential anti-lipotoxic effect of nicotinamide and to elucidate underlying mechanism(s). as IRE1a inhibitor to study its effect on NOS 2 expression and investigate the underlying mechanisms in proinflammatory gene expression in astrocytes. to block endogenous XBP1 cleavage for one hour prior to palmitate exposure in order to examine whether inositol?requiring enzyme 1伪 (IRE1伪 ) activation is implicated in palmitate cytotoxicity
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