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Zymosan A from Saccharomyces cerevisiae has been used:. as a positive control to determine the activation of complement cascade. for respiratory burst (RB) assay. to assess its effects on performance, immunity, heat shock protein and apoptosis related gene expressions of dairy cows under heat stress (HS). a stimulating agent in Krebs-Ringer phosphate (KRP) medium. to induce thermal hyperalgesia in mice